Imiquimod/β-Cyclodextrin Inclusion Complex: Experimental and Theoretical Studies
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چکیده
منابع مشابه
Experimental and Theoretical Investigations on the Supermolecular Structure of Isoliquiritigenin and 6-O-α-d-Maltosyl-β-cyclodextrin Inclusion Complex
Isoliquiritigenin (ILTG) possesses many pharmacological properties. However, its poor solubility and stability in water hinders its wide applications. The solubility of bioactive compounds can often be enhanced through preparation and delivery of various cyclodextrin (CD) inclusion complexes. The 6-O-α-D-maltosyl-β-CD (G2-β-CD), as one of the newest developments of CDs, has high aqueous solubil...
متن کاملΒ-cyclodextrin Inclusion Complex of Curcumin
Formation of inclusion complex of curcumin with β-cyclodextrin ( β-CD) has been characterized by absorption and fluorescence spectroscopy. From temperature-dependent fluorescence measurements, the thermodynamic parameters ∆H and ∆S, for the complexation were estimated. Kinetics of binding was studied by stopped flow technique, from which the binding constants for inclusion complex was estimated...
متن کاملPreparation, Physicochemical Characterization and In-vitro Dissolution Studies of Diosmin-cyclodextrin Inclusion Complexes
Diosmin, a vascular-protecting agent, is practically insoluble in water, and its oral absorption is limited by its extremely low dissolution rate. In this study, β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPβCD) were obtained to improve the solubility and dissolution rate of diosmin. Phase solubility studies of diosmin with βCD and HPβCD in distilled water were conducted to charac...
متن کاملPreparation, Physicochemical Characterization and In-vitro Dissolution Studies of Diosmin-cyclodextrin Inclusion Complexes
Diosmin, a vascular-protecting agent, is practically insoluble in water, and its oral absorption is limited by its extremely low dissolution rate. In this study, β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPβCD) were obtained to improve the solubility and dissolution rate of diosmin. Phase solubility studies of diosmin with βCD and HPβCD in distilled water were conducted to charac...
متن کاملStudy of inclusion complex of beta-cyclodextrin and nitrobenzene.
beta-cyclodextrin can react with nitrobenzene to form an inclusion complex which is characterized by (1)H NMR and powder X-ray diffractometry. The ratio of beta-CD to NB in inclusion complex is determined as 1:1. At 25 degrees C, the dissociated constant, K(D), of the inclusion complex is measured as 6.5 x 10(-3) M in neutral solution (pH=7.0), but in alkali (pH=13.5), K(D) is 3.2 x 10(-2) M wh...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2020
ISSN: 0103-5053
DOI: 10.21577/0103-5053.20200060